The One North LaSalle Building or One LaSalle Street Building is a building in the LaSalle Street corridor in the Loop community area of Chicago. It was for some time one of Chicago's tallest buildings. Built in 1930 by architects Vitzthum & Burns, it replaces the Tacoma Building by Holabird & Roche. The building is located across Madison Street from Roanoke Building. It was designated a Chicago Landmark on April 16, 1996, and added to the National Register of Historic Places on November 22, 1999. Its 5th floor relief panels depict the explorations of René-Robert Cavelier, Sieur de La Salle.
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